Abstract
Osteocompetent cells, such as hypertrophic chondrocytes, osteoblasts and odontoblasts, release a special class of extracellular vesicles called matrix vesicles (MVs) that are involved in the deposition of apatite minerals at the sites of bone and tooth calcification. During the formation of physiological and pathological calcifications, MVs are believed to be released by outward budding o…