Abstract
Among the arboviruses that occur in Brazil, flaviviruses stand out due to the large number of epidemics caused, such as those caused by dengue, yellow fever and Zika viruses. In addition to the medically important flaviviruses, there is also the group of insect-specific flaviviruses (ISFs), which do not replicate in mammalian cells and do not have a clear definition of their role in the d…