Abstract
Microbial agents have been used to fight cancer for over 100 years. Bacteria are capable of inducing death or activating the immune system against tumor cells. Since its initial proposal by William Coley, different bacteria have been used, including Streptococcus, Clostridium and the successful use of the bacillus Calmette-Guérin (BCG) from Mycobacterium bovis to treat bladder cancer. But…