Abstract
Cerebral malaria is characterized by proliferation of Th1-profile CD4+ T cells and CD8+ T cells (CTLs) in the spleen, which migrate to the cerebral microvasculture, promoting dysfunction of the blood-brain barrier (BBB). In the parenchyma, CTLs and Th1 cells contribute to the reactivity of glial cells, inducing neuroinflammation, promoting cell death and increasing levels of extracellular…