Abstract
Clavulanic acid (CA) is a potent inhibitor of beta-lactamases, enzymes that deactivate penicillins and cephalosporins by hydrolyzing the beta-lactam ring. CA is traditionally produced by Streptomyces clavuligerus in batch and fed-batch cultures with free cells in conventional bioreactors. The aim of the present project is to study the production of clavulanic acid by Streptomyces clavulig…