Abstract
The NLRC4 inflammasome is a multiprotein platform involved in the activation of caspases effects from the recognition of different microbes in the cytosol. After the recognition of bacterial flagellin, NAIP5/NLRC4 lead to activation of caspase-1 (CASP1) and caspase-7 (CASP7), promoting host resistance to infection through a deathprogrammed cell known as pyroptosis.Legionella pneumophila i…