Abstract
6-Nitrodopamine (6-ND) is released by the endothelium of human umbilical cord vessels, aortic rings of the tortoise Chelonoidis carbonarius and aortic rings of the snake Panterophis guttatus. In these vascular tissues, 6-ND is a potent vasodilator, acting as a highly selective antagonist for dopamine D2-like dopamine receptors. The synthesis/release of 6-ND is coupled to the synthesis of …