Has experience in Biochemistry, focusing on Molecular Biology (Source: Lattes Curriculum)
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HIF-1¿ (hypoxia-inducible factor-1¿) is a transcription factor involved in the regulation of genes associated with glycolytic metabolism and lactate production pathways. In macrophages, HIF-1¿ is activated in response to PAMPs, such as lipopolysaccharide (LPS). This activation leads to reprogramming of carbohydrate and lipid metabolism and promotes inflammation. MicroRNAs are small non-co…
In this project, we aim to understand the function of miR-372 and miR-373 in the regulation of HIF1A and its network of target genes and the impact on the response of macrophages infected with Leishmania infantum. We formulate the hypothesis that infection with L. infantum leads an increase the of miR-372/373 expression and these molecules alter the levels of HIF-1± mRNA/protein and, cons…
In this project, we aim to evaluate the function of miR-372/373 in the regulation of glucose metabolism in macrophages infected with Leishmania infantum. We hypothesize that the infection with L. infantum increases the expression of human miR-372/miR-373, and these molecules alter the mRNA/protein levels of HIF-1± and consequently a network of target genes involved in glycolysis in macrop…
| 1 / 1 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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CV Lattes
ORCID