Abstract
Saliva is essential for lubrication, digestion, protection against pathogens, and maintenance of acid-base balance. Diacerein, an anti-inflammatory agent that inhibits pro-inflammatory cytokines such as TNF-± and IL-1², has been clinically used in cases of osteoarthritis. The detrimental effects of diacerein on the testicular function of rodents, under normal conditions, have been reporte…