Abstract
In this project, we aim to evaluate the function of NALP12 and microRNA-294 in regulating the response of macrophages infected with L. amazonensis. We hypothesized that infection with L. amazonensis changes the expression of the NLR family, pyrin domain containing 12 (NALP12) and the microRNA encoded in the antisense strand into NALP12 gene, microRNA-294. The set of signals mediated by t…