Abstract
Doxorubicin (dox) induced cardiotoxicity is one of the most important side effects of this chemotherapeutic drug, seeing as it can lead to oncological patients developing cardiomyopathies. Dox produces free radicals and inhibits topoisomerase II, which results in several DNA breaks followed by genotoxic stress culminating in cardiomyocyte death. Multiple studies show that Focal Adhesion K…