CV Lattes
ORCID
Abstract
Lung cancer is the most lethal type of cancer, and the high mortality rate is associated to the late detection of disease when most patients already have distant metastases, reducing 5-years survival to 20%. Lung oncogenesis is related to activating mutations in the MAPK signaling such as KRAS and EGFR, and inactivating mutation in the TP53 gene. However, murine models bearing these mutat…