Abstract
Down syndrome (DS), also known as trisomy 21 (T21), which involves the presence of an extra copy of human chromosome 21 (HSA21), is the most common autosomal aneuploidy in live births. Intellectual disability is present in 100% of individuals, many of whom continue to experience learning and memory impairments and a higher risk of developing a neuropathology indistinguishable from Azheime…