CV Lattes
ORCID
Abstract
The Klotho gene has been associated with longevity in mice, demonstrating accelerated early aging after silencing or increased life expectancy when the gene is overexpressed.The Klotho protein has transmembrane and secreted forms, with distinct functions, among them the regulation of ion channels and growth factor receptors. In addition to acting as a co-receptor for fibroblast growth fac…