Abstract
The PI3K-mTORC2-Akt-mTORC1 pathway regulates lipid and glucose metabolism in white and brown adipocytes through unknown mechanisms that involves the transcriptional factors SREBP1 e PPARgama, among others. One of the main issues to study these mechanisms is related to the intricate crosstalk between mTORC2-Akt and mTORC1 (mTORC2-Akt activates mTORC1, while mTORC1 inhibits mTORC2-Akt), imp…