CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Nursing from the Federal University of São Carlos. During graduation, she was a physiology, biochemistry and biophysics tutor, student representative on the UFSCar University Council and served as Coordinator of the UFSCar Academic Nursing Center. Conducted research in the area of #8203;#8203;Mental Health (PIBIC/CNPq Scholarship 2019-2020) evaluating and validating the cross-cultural translation of the Positive Expectations Scale on alcohol use into Brazilian Portuguese. Completed graduation with supervised internship in the sector of Continuing and Permanent Education and Home Care Service of Santa Casa de Misericórdia de São Carlos and Primary Health Care in the same city. worked as a Parliamentary Advisor to the São Paulo City Council, responsible for the Public Health area from 2021 to 2024. She is currently a master's student, as FAPESP scholarship recipient, at the Pain and Signaling Laboratory of the Butantan Institute with the project entitled: Molecular mechanisms involved with adverse effects associated with the specific use of morphine: role of the TRPA1 receptor and the aldehyde dehydrogenase-2 enzyme, under the guidance of Dr. Vanessa Zambelli (Source: Lattes Curriculum)
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Opioids are currently the most widely used drugs in clinical practice for the treatment of moderate to severe pain. However, chronic use of these analgesics triggers adverse effects, such as tolerance to their analgesic effect and a decrease in nociceptive threshold, a phenomenon known as hyperalgesia. These effects generally lead to the need for dose escalation during treatment to achiev…
Chronic opioids often lead to tolerance and paradoxical hyperalgesia, limiting therapeutic efficacy. Transient receptor potential ankyrin 1 (TRPA1) ion channels, activated by reactive aldehydes, such as 4-hydroxynonenal (4-HNE), are involved in nociceptive signaling. Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme responsible for 4-HNE detoxification. Previous data have shown t…
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