Abstract
Introduction: Pre-eclampsia (PE) is a pregnancy-specific syndrome characterized by high plasma levels of pro-inflammatory cytokines, such as tumor necrosis factor (TNF), which play an important role in the pathophysiology of the disease. The binding of TNF to the TNFR1 and TNFR2 receptors on the cell surface activates different signaling pathways. TNFR1 induces cell death by apoptosis or …