Abstract
The hormone T4 enters the cells through transporters expressed in the plasma membrane and is converted to T3, the active form of thyroid hormone, by the deiodinases. Approximately 12 to 36% of the global population carries a single nucleotide polymorphism (SNP) in the DIO2 gene (rs225014) that encodes type 2 deiodinase (D2), resulting in the Ala92-D2 polymorphism. Studies published by our…