Abstract
The increased incidence of mitotic catastrophe, a form of cell death that is considered to represent an onco-suppressive pathway, has been associated to depletion of DNA methyltransferase I (DNMT1), enzyme which exerts influence on the DNA methylation status. In the cervical tumorigenesis, DNMT1 affects the activity of several suppressor genes. HeLa cells, a cell line originated from cer…