CV Lattes
ORCID
Abstract
Parkinson's disease (PD) is a neurodegenerative disease, with central pathophysiology reflecting the loss or degeneration of dopaminergic neurons in the substantia nigra. Pharmacological approaches to PD aim to rebalance the dopamine deficit, mainly with levodopa replacement. Although the introduction of dopaminergic replacement therapies alleviated the motor symptoms of PD, the natural h…