Abstract
The medullary thyroid carcinoma (MTC) may be associated with Multiple Endocrine Neoplasia type 2 (MEN2) when it results from germline mutations in the RET proto-oncogene. Our hypothesis is that the geographic spread of the pathogenic variants V804L and V804M in the RET gene throughout the Brazilian territory may be attributed to a founder effect. The aim of our project is to describe the …