Abstract
Stressful stimuli play a crucial role in the pathogenesis of psychiatric disorders such as Post-Traumatic Stress Disorder (PTSD). The isoforms of the nitric oxide synthase (NOS) enzyme-neuronal (nNOS), inducible (iNOS), and endothelial (eNOS)-are responsible for nitric oxide (NO) production, a critical factor in fear responses. In the central nervous system (CNS), the primary NO synthesis…