Abstract
INTRODUCTION: In dentistry, pain is a frequent challenge, and topical anesthetics, such as lidocaine (LDC) and prilocaine (PLC) in 5% cream, are used to relieve pain during puncture. However, inefficient superficial anesthesia leads to the search for alternatives, such as amitriptyline and spilanthol, which, when combined with nanotechnology, may improve the effectiveness and safety of tr…