Abstract
The polyriboinosinic-polyribocytidylic acid (Poly-ICLC), also known as Hiltonol®, is a double-stranded RNA macromolecule that has demonstrated versatility in modulating the immune profile of humans in response to pathogens, both as initial therapy and as a complement in various diseases, including autoimmune, neoplastic, and infectiousdiseases. Its ability to induce type 1 interferons (IF…