CV Lattes
ORCID
Abstract
Transcription factors (TF) are usually considered to be poorly druggable, but this perception stems from the fact that eukaryotic TFs are predominantly intrinsically disordered proteins, which are indeed harder to inhibit with small molecules (10.1038/s41573-021-00199-0). Bacterial TFs, on the other hand, are structured and naturally regulated by small molecule allosteric modulators. The …