Abstract
The prohormone T4 enters target cells through transporters expressed in the plasma membrane, where it can be converted into its active form T3 by the action of deiodinases. Approximately 12 to 36% of the global population exhibits a single nucleotide polymorphism (SNP) in the DIO2 gene (rs225014) that codes for type 2 deiodinase (D2), resulting in the Ala92-D2 polymorphism. Studies conduc…