Abstract
Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors derived from chromaffin cells of the adrenal medulla (pheochromocytomas, representing 80% of cases) or from the thoracic and abdominal paravertebral sympathetic ganglia, or from the head and neck parasympathetic ganglia (paragangliomas, accounting for 20% of cases). PPGLs are caused by germline pathogenic or likely pat…