Abstract
In neoplasms, ROS act as signaling molecules contributing to tumorigenesis. The antioxidant response is mediated by the Keap1-NRF2-ARE complex, negatively regulated by the BACH1 gene. In breast cancer, elevated BACH1 expression is linked to increased recurrence, while its decrease reduces the risk of metastasis. BACH1 also influences IRE1±, crucial in endoplasmic reticulum (ER) homeostasi…