CV Lattes
ORCID
Abstract
Primary endodontic infection (PEI) is complex and involves a polymicrobial profile that can lead to apical periodontitis (AP). This periapical inflammatory response is mediated by cytokines such as IL-1 and TNF-alpha, which regulate bone remodeling and osteoclastic activity. Chronic stress alters body homeostasis and the immune system, potentially negatively impacting endodontic treatment…