Abstract
The regeneration of periodontal structures depends on the activation and differentiation ofmesenchymal cells from the periodontal ligament (PDLMSCs), which are responsible for formingnew cementum, alveolar bone, and periodontal ligament. However, these cells areheterogeneous, with approximately 80% displaying low osteogenic potential (LOP). Previousstudies identified the Asporin (ASPN) ge…