Alexandre Ferro Aissa

• Abstract

  The clinical use of antitumor drugs is usually accompanied by various side effects that compromise patients' quality of life. Therefore, the search for new antitumor agents with greater efficacy and fewer side effects has been intense. In this sense, dietary bioactive compounds such as catechins have become an interesting source in the search for these drugs. One catechin, namely epigallo…

  A 3D culture model of human HepG2 cells for evaluation of the cytotoxicity and genotoxicity of epigallocatechin-3-gallate, BP.IC

• Abstract

  The use of the 3Rs (Reduction, Refinement, and Replacement) was proposed as an alternative for replacing the use of animals in research in order to minimize the number of animals used and to refine the experimental design so as to cause the least possible amount of pain. The importance of applying new alternative methods to the use of animals has led to the creation of new in vitro method…

  Nutri-epigenetics: evaluation of the effects of epigallocatechin-3-gallate on epigenetic events in genes and proteins related to cell proliferation in multicellular tumor spheroids in three dimensional culture (3D), BP.PD

• Abstract

  Epigenetics can be defined as the study of heritable changes of a phenotype such as gene expression patterns that are not caused by changes in the nucleotide sequence or the genetic code. Among the most studied epigenetic mechanism is DNA methylation. This process is the addition of a methyl at carbon number five of the aromatic ring of cytosine, to form the basis methylcytosine. Mammalia…

  Gene-diet interaction in mice supplemented with methionine in the fetal and postnatal periods: studies of genomic instability, methylation and expression of genes related to cardiovascular diseases, BP.DR

(Only some records are available in English at this moment)

• Abstract

  In the last decade, significant advances have been achieved with regard to the effort to decipher the molecular mechanisms responsible for the impact of nutritional factors in gene regulation, especially pertaining to processes that do not involve the modification of the genetic code. With the elucidation of the mechanisms controlling epigenetic events, such as DNA methylation, acetylatio…

  MicroRNA expression analysis in female mice treated with methionine-deficient or -supplemented diets during pregnancy, BE.EP.DR