CV Lattes
ORCID
Abstract
Sickle cell disease is a hereditary disease of high relevance worldwide caused by a mutation in the gene that encodes the b subunit of hemoglobin, which forms an anomalous hemoglobin (HbS), which polymerizes during deoxygenation, forming sickle-shaped erythrocytes. This condition can lead to several clinical complications, most of which are associated with episodes of vaso-occlusion, a ph…