Abstract
CYP3A4 and CYP3A5 are cytochrome P450 enzymes responsible for the biotransformation of endogenous steroids and xenobiotics. Statins are HMG-CoA reductase inhibitors used in the treatment of the hypercholesterolemia. Single nucleotide polymorphisms (SNPs) in CYP3A4 and CYP3A5 genes (CYP3A4*1B and CY3A5*3C) had been associated with differences in the hipolipemiant response of individuals tr…