Abstract
The purpose of the present study is to evaluate the osseointegration of titanium implants placed in the tibias of rats, systemically modified or not by Caffeine (CAF) combined or not with Nicotine (NIC). A total of 60 rats will be used, distributed into three experimental groups (n=20). The animals will receive caffeine at a dose of 20 mg/kg daily (once per day) and nicotine at a dose of …