Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used class of medication for the treatment of pain, fever and inflammation, being regularly administered even to pregnant and lactating women. These drugs have an inhibitory effect on the Cyclooxygenase enzyme (COX-1 and COX-2), leading to a reduction in PGE2. Additionally, NSAIDs can act as endocrine disruptors. Studies …