Abstract
The cytotoxic function of NK cells is regulated by the balance of activation and inhibition signals from receptors expressed on the NK surface. These receptors interact with various ligands on the target cells. Among these receptors are those of the NKG2/CD94 cluster, encoded on chromosome 12, with six known members: KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and KLRD1. These genes originated fro…