CV Lattes
ORCID
Abstract
As the life expectancy of individuals with Down Syndrome (DS) increases, they exhibit dementia-related aging associated with the development of Alzheimer's Disease (AD), partly because the amyloid precursor protein (APP), which plays a crucial role in AD pathogenesis, is located on chromosome 21-the same chromosome affected by trisomy in DS. Consequently, the overexpression of the APP gen…