CV Lattes
ORCID
Abstract
The development of tumors associated with HPV infection results from persistent infections with high-risk oncogenic HPVs, with HPV-16 being the most prevalent worldwide in both pre-neoplastic lesions and cancers of different anatomical sites. The E6 and E7 oncoproteins of high-risk HPVs associate with and inactivate, respectively, the tumor suppressor proteins p53 and pRb, which results i…