ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Nicolas Jones Villarinho in research grants and scholarships supported by FAPESP.
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Uveal melanoma (UM) is the most aggressive form of ocular cancer, poses a formidable challenge due to its high metastatic propensity, a leading cause of patient mortality. Effective therapies for UM metastasis remain elusive. Based on solid preliminary data, in this project I posit that loss of 15-hydroxyprostaglandin dehydrogenase (HPGD), a tumor suppressor gene, promotes UM aggressivene…
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