Abstract
During chronic Chagas disease cardiomyopathy (CCC), inflammatory cytokines IFN-gamma and TNF-alpha have been implicated in the pathogenesis and progression of heart disease. Previous studies from literature have shown that both IFN-gamma and TNF-alpha are able to deteriorate in vitro electromechanical function of mouse cardiomyocytes Recently, our group has shown that both cytokines impa…