Abstract
The permeable phosphopeptide TAT-pQYP has been shown to reverse acute nociception in inflammatory models by inhibiting the anchoring of Phospholipase-Cg (PLCg) to the phosphorylated Y785 of Tropomyosin kinase A (TrkA), thereby inhibiting the phosphorylation and activation of the lipase by TrkA and peptide signaling in the nociceptors of the dorsal root ganglion (DRG). The hypothesis of th…