Abstract
The mitochondrial NAD(P)+ transhydrogenase (NNT) catalyzes the transfer of a hydride between NADH and NADP+ coupled to the entry of a proton from the intermembrane space into the mitochondrial matrix. The NADPH generated by NNT activity provides reducing power to peroxide detoxification systems and to anabolic reactions. In recent years, brown adipose tissue (BAT) has attracted increasing…