Abstract
The NLRP3 inflammasome plays a critical role in the innate immune system, and thus in inflammatory and homeostatic processes. The TMEM176B channel, in turn, negatively regulates this complex by controlling caspase-1 activation and the secretion of inflammatory cytokines IL-1¿ and IL-18, as well as modulating Ca2+ and K+ fluxes. Studies have been exploring TMEM176B as a target in cancer im…