Alexandre Holthausen Campos

• Abstract

  The development of atherosclerosis involves the activation/modification of several cell types, including endothelial, vascular smooth muscle (VSMC) and immune cells, such as monocytes, macrophages, dendritic cells and T lymphocytes. In a previous study, we demonstrated that BMPs (-2 and -4), as well as the BMP antagonist Gremlin, are supra-regulated in aortas and in VSMC from animals pron…

  Role of the BMP signaling pathway in the recruitment of cells from the immune system in the progression of atherosclerosis., AP.R

• Abstract

  Atherosclerosis (ATS) is a chronic vascular disease and a major cause of death worldwide. Monocytes and macrophages, along with vascular smooth muscle cells (VSMCs), play essential roles in all phases of atherogenesis. Bone morphogenetic proteins (BMPs) have been associated with ATS development, including induction of vascular calcification and inflammation. Preliminary data from our lab …

  Role of BMP signaling in monocyte recruitment and atherosclerotic plaque formation: a study in mouse models and humans, AP.R
• In vitro and in vivo analysis on the role of gremlin, a TGF-beta/BMP pathway antagonist, on the development of atherosclerosis in ApoE knockout mice: a study on vascular smooth muscle cell phenotype., AP.R

(Only some records are available in English at this moment)

• Abstract

  The development of atherosclerosis involves the activation and modification of various cell types, such as vascular smooth muscle cells (VSMC), endothelial cells and cells of the immune system. Genes such as BMPs and their antagonist Gremlin are related to the pathophysiology of this disease. To investigate this, we established a line of mice susceptible to plaque formation and gaining BM…

  Action of the Gremlin gene on the profile of monocytes and macrophages in the progression of atherosclerosis, BP.IC

• Abstract

  Atherosclerosis (ATS) is a chronic inflammatory disease of the arterial wall and a major cause of death worldwide. Vascular smooth muscle cells (VSMC) play a crucial role in all stages of atherogenesis. Phenotypic changes in those cells are associated with the progression and instability of atherosclerotic plaque, and the resulting clinical manifestations, such as acute myocardial infarct…

  DEDIFFERENTIATION OF VASCULAR SMOOTH MUSCLE CELLS IN THE DEVELOPMENT OF ATHEROSCLEROSIS - THE ROLE OF BMP SIGNALING, BP.MS

• Abstract

  Diabetic nephropathy is a leading cause of end-stage renal disease, which is associated with high morbidity and mortality rates. Factors and mechanisms involved in renal injury due to diabetes are complex and poorly understood. TGF-b1, a cytokine which regulates the expression of different classes of genes, induces phenotypic modifications in glomerular cells. Recent data from our laborat…

  The role of gene Dapper1 a Wnt pathway inhibitor, in apoptosis triggered by TGF-beta in mesangial cells, BP.DD

(Only some records are available in English at this moment)