Abstract
Hereditary Spastic Paraplegia type 4 (SPG4) is the most common form of Hereditary Spastic Paraplegia (HSP), a clinically and genetically heterogeneous group of neurodegenerative diseases. The core feature of HSPs is the degeneration of corticospinal tract axons, which causes progressive weakness and spasticity in the lower limbs. Despite a global incidence of 3.6 cases per 100,000 individ…