Abstract
Classical Hodgkin Lymphoma (CHL) is a B-cell malignancy associated with Epstein-Barr virus (EBV) infection and modulated by inflammatory mediators. The production and secretion of these mediators by Hodgkin and Reed-Sternberg cells in the tumor microenvironment can lead to CHL progression. The disease progression compromises the patient's quality of life, increases the risk of relapse or …