CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's degree in Pharmacy-biochemistry at the Faculty of Pharmaceutical Sciences of University of Sao Paulo (2011), master's degree (2013) and PhD degree (2020) at Physiology and Biophysics at the Institute of Biomedical Sciences of University of Sao Paulo. I have completed 12 months of PhD exchange (2018-2019) at the Biophysics Department at Zentrum für Human- und Molekularbiologie (ZHMB) - Universität des Saarlandes (Homburg, Germany). I have a postdoc (2021-2023) at the Energy Metabolism Laboratory of the Biochemistry Department (Chemistry Institute - USP), under the supervision of Professor Alicia Kowaltowski, where I studied the regulation of energy metabolism by mitochondrial calcium transport in the liver. My research interests are strongly focused in the pathophysiology of the pancreatic beta cell, with emphasis on the chronic effects of fatty acids, pro-inflammatory cytokines and signaling molecules, such as reactive oxygen species and NAD(P)H, on redox changes involved in the functionality and survival of the pancreatic beta cell. Currently, Im a Professor Doctor, fully dedicated to teaching and research in the Department of Clinical and Toxicological Analysis of the Faculty of Pharmaceutical Sciences at USP. My research interests involve the study of the pathophysiology of the pancreatic beta cell, with an emphasis on the interaction between redox state and calcium homeostasis and the use of new and robust tools for evaluating reactive oxygen species and calcium. E-mail address: elovilasboas@usp.br (Source: Lattes Curriculum)
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In type 1 diabetes mellitus (T1D), there is an absolute insulin deficiency due to an autoimmune destruction of pancreatic beta cells. In type 2 diabetes mellitus (T2D), there is a progressive loss of insulin secretion, associated to various degrees of peripheral resistance to the hormone action. In both cases, the common outcome is chronic hyperglycemia and its associated complications. T…
Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia that, when not treated adequately, can lead to a series of complications and a decrease in the quality and life expectancy of patients. One of the main types of DM is DM type 2 (DM2), which is closely related to obesity and metabolic syndrome. During the progression of DM2, the exposure of beta cells to high concen…
Mitochondria are organelles responsible for the efficient generation of ATP through the metabolism of carbohydrates, lipids and proteins. They are dynamic organelles, which undergo a constant change in size and shape over time, through mitochondrial fusion and fission processes. The mitochondrial inner membrane has a negative internal potential, essential to sustain oxidative phosphorylat…
Pyruvate dehydrogenase, isocitrate dehydrogenase, and a-ketoglutarate dehydrogenase of the mitochondrial matrix have been shown to have increased activities in the presence of Ca2+ ions in vitro (Denton and McCormack, 1985; Hansford, 1985). However, these studies were conducted modulating isolated enzyme activity, and show increases in substrate affinity, but not universally in maximum ve…
The plasmatic concentration of glucose is the main insulin secretion modulator, hormone produced and secreted from pancreatic islets beta cells. However, other nutrients, such as fatty acids, are also capable of modulating this secretion, through mechanisms still not elucidated. The fatty acids effects in insulin secretion and in the beta cell normal function are controversial. Acutely, t…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 6 / 5 | All research grants and scholarships |
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