Abstract
Amyotrophic Lateral Sclerosis (ALS) is an adult-onset and fast progression neurodegenerative disease promoted by the loss of motor neurons, leading to death within 2-5 years. Glial cells have been implicated in the neuronal death by releasing toxic factors or by loosing physiological functions. The interaction between the prion protein (PrPC) in the neuronal surface and its ligand STI1, r…