CV Lattes
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Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina Veterinária from Universidade Estadual Paulista Júlio de Mesquita Filho (1988), master's at Zoothecny from Universidade Estadual Paulista Júlio de Mesquita Filho (1993) and doctorate at Veterinary Medicine from Universidade de São Paulo (1997). Has experience in Veterinary Medicine, acting on the following subjects: embriões, bloqueio meiótico, bovino, butirolactona i and oócito. (Source: Lattes Curriculum)
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The epigenetic mechanisms that render the oocyte competent for development are important issues in female gamete biology, and a better understanding of these basic phenomena offers an opportunity to improve biotechnologies with benefits for humans and animals. This project aims to use an oocyte competence study model, based on the induction of temporary and reversible meiotic arrest (pre-…
In vitro-produced bovine embryos (IVP) have morphological, molecular, and, mainly, metabolic alterations, such as lipid accumulation, which leads to lower cryotolerance. Fetal bovine serum (FBS) is among the most used sources of macromolecules in culture media during IVP. Besides, it is considered one of the main factors responsible for the increase in lipid accumulation of these structur…
The epigenetic mechanisms governing the ability of the female gamete, i.e. the oocyte, to become totipotent are at the center of many unanswered questions in biology and a better understanding of such a basic phenomenon offers a unique opportunity to develop novel biotechnologies with wide-reaching benefits for humans and animals. This thematic project brings together renowned Canadian an…
In vitro production (IVP) of embryos is a widely used reproductive biotechnique, but quality of embryos is still suboptimal; such embryos show greater sensibility to cryopreservation and increased cytoplasmic lipid accumulation. In vitro culture (IVC) of embryos with extracellular vesicles (EVs) from bovine oviductal fluid (ofEVs), as well as the use of fetal calf serum (FCS) depleted fro…
Melatonin (MLT) is an indoleamine that can act on reproductive competence, has antioxidant and antiapoptotic activities and influences different cell signaling pathways. In vitro studies have shown beneficial effects of MLT use on in vitro maturation (IVM) and culture (IVC) of bovine oocytes and embryos, respectively. In addition, MLT is able to induce the resumption of meiosis, but the m…
(Only some records are available in English at this moment)
Epigenetic mechanisms underlying oocyte totipotency and developmental competence remain largely unknown. A better understanding of these fundamental processes offers opportunities for developing novel biotechnologies with benefits for both humans and animals. This study is part of the São Paulo Excellence Chair (SPEC-FAPESP) thematic project "Epigenetic maturation of the oocyte and totipo…
In vitro-produced bovine embryos (IVP) have morphological, molecular, and, mainly, metabolic alterations, such as lipid accumulation, which leads to lower cryotolerance. Fetal bovine serum (FBS) is among the most used sources of macromolecules in culture media during IVP. Besides, it is considered one of the main factors responsible for the increase in lipid accumulation of these structur…
Although in vitro production (IVP) of embryos is well established technique in bovie, the quality of embryos is still suboptimal; such embryos show, among other factors, greater sensibility to cryopreservation associated with increased cytoplasmic lipid accumulation. In vivo culture cumulus-oocyte complexes (COCs) develop and mature within the follicular fluid (FF) and embryos start their…
Epigenetic mechanisms that govern the ability of the female gamete (the oocyte) to become totipotent are at the heart of many unanswered questions in biology. A better understanding of these basic phenomena offers the opportunity to develop new biotechnologies with benefits for humans and animals. This proposal is part of the São Paulo Excellence Chair (SPEC-FAPESP) thematic project "Epig…
In vitro-produced bovine embryos (IVP) have morphological, molecular, and, mainly, metabolic alterations, such as lipid accumulation, which leads to lower cryotolerance. Fetal bovine serum (FBS) is among the most used sources of macromolecules in culture media during IVP. Besides, it is considered one of the main factors responsible for the increase in lipid accumulation of these structur…
Melatonin (MEL) is an indoleamine that can act on reproductive competence, has antioxidant and antiapoptotic activities and influences different cell signaling pathways. In vitro studies have shown contradictory effects of MEL on in vitro maturation (IVM) and culture (IVC) of oocytes and embryos, respectively, in several species. In this study, we propose to investigate the effect of MEL …
(Only some records are available in English at this moment)
Although it has already reached a commercially relevant number, in vitro embryo production still faces an important challenge: overcoming the asynchrony between nuclear, cytoplasmic, and molecular maturations that occurs in the cumulus-oocyte complexes (COC) aspirated from small-mid antral follicles, which are still at different stages of germinal vesicle (GV), in a way that provides a be…
In vitro production (IVP) of embryos is a widely used reproductive biotechnique, but quality of embryos is still suboptimal; such embryos show greater sensibility to cryopreservation and increased cytoplasmic lipid accumulation. In vitro culture (IVC) of embryos with extracellular vesicles (EVs) from bovine oviductal fluid (oEVs), as well as the use of fetal calf serum (FCS) depleted from…
Previous studies have shown that bovine cumulus-oocyte complexes (COCs), express transcripts for several enzymes of the cGMP pathway including those for its synthesis (GUCY1B3), degradation (PDE5A) and signaling (PKG1 and PKG2), and that FCS in IVM medium affects the expression of some of these transcripts, as well as decreases cGMP levels. Inhibition of cGMP hydrolysis with PE% inhibitor…
Melatonin (MLT) is an indoleamine that can act on reproductive seasonality in some species, has antioxidant and antiapoptotic activities and influences different cell signaling pathways. In vitro studies have shown beneficial effects of MLT use on in vitro maturation (IVM) and culture (IVC) of bovine oocytes and embryos, respectively. In this study, we propose to investigate the effects o…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 16 / 11 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 22 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 51 / 37 | All research grants and scholarships |
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