Ana Paula de Souza

• Abstract

  Enhancers are regions in the genome known as cis-regulatory elements. They have a key role guiding the cell type specific expression and are able to regulate the transcriptions of their targets genes from great distances. The chromatin accessibility as well as the DNA methylation can control the enhancer activity .Recently, we have demonstrated a new regulatory region located at SOCS1 CGI…

  ANALYSIS OF THE CHROMATIN INTERACTION IN THE REGION OF SOCS1 GENE, AP.R

• Abstract

  The infection-inflammation has been suggested as a factor involved in the etiology of several cancers, including oral cancer. Epidemiologic data support this hypothesis since connective tissue loss derived from chronic periodontitis has been associated with high risk to development of oral cancer (OR=4,57, 95% CI:2,25-9,30) and premalignant lesions of oral cavity (OR=1,55, 95% CI:1,06-2,2…

  Periodontal inflammation, oxidative and nitrative stress and DNA methylation, AP.JP
• Analysis of genes promotor methylation of IL-8, iNOS, TIMP-2, TIMP-3 in smoking and no-smoking patients with chronic periodontitis: association with genetic transcription of these genes in gingival tissue, AP.R

• Abstract

  Enhancers are regions in the genome known as cis-regulatory elements. They have a key role guiding the cell type specific expression and are able to regulate the transcriptions of their targets genes from great distances. The chromatin accessibility as well as the DNA methylation can control the enhancer activity .Recently, the PhD results demonstrated a new regulatory region located at S…

  Analysis of the chromatin interaction in the region of SOCS1 gene, BP.PD

• Abstract

  The production of oxygen-derived and nitrogen-derived reactive molecules during chronic inflammation creates oxidative and nitrative stress in cells. These molecules can damage proteins, lipids and DNA. Among the changes promoted by these reactive molecules are the alterations in the pattern of DNA methylation in CpG dinucleotides of regions that control gene transcription. Methylation of…

  Analysis of Oxidative Stress Influence on DNA Methylation Profile, BP.PD
• DNA methylation analysis in the promoter of EZH2 gene in oral cells: association with aging., BP.IC

(Only some records are available in English at this moment)

• Abstract

  Enhancers are regions in the genome known as cis regulatory elements. They play a central role guiding gene expression that generates cell specificity, being able to activate transcription of its target genes over long distances. Both chromatin condensation and DNA methylation are capable of inhibiting the activity of enhancers. The postdoctoral scholarship in the country is intended to s…

  Investigation of the mechanisms that control DNA methylation changes in the region of SOCS1 gene, BE.EP.PD